[PubMed: 29274590]. Sadoughi [PubMed: 14687888]. extract International Journal of Green Pharmacy • July-Sep 2018 (Suppl) • 12 (3) | S529 human defense system against various diseases and stress condition. Next, blood serum was isolated to measure the serum levels of TNF-α, IL-1β, and IL-6, using ELISA kits (FineTest, China). Affiliation: Medicine Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Then, A. marina species was identified and confirmed at the Herbarium Department of the Payam Noor University of Mashhad, Iran (herbarium code: 12/3254). [PubMed: 26597598]. Davi G, Falco A, Patrono C. Lipid peroxidation in diabetes mellitus. Diabetes may lead to morphological changes and hepatocyte damage. 7 ). All the extracts possessed significant On the other hand, if the message is transmitted through surface receptors, the transmission is facilitated by adapter molecules to the caspase cascade (7). Managing diabetes and liver disease association. The plates were prepared in duplicates and allowed to set at room temperature. It is also likely that the constituents of mangrove plants can cause hypertrophy of beta cells in the remnant pancreas, leading to increased insulin secretion in type 1 DM rats (31). 2018;19(4):166-79. doi: 10.1016/j.ajg.2018.08.003. [PubMed Central: PMC3359690]. This experimental research was conducted in the Research Center of Baqiyatallah University of Medical Sciences, Tehran, Iran, in 2018. J Diabetes Complications. Gum arabic improves semen quality and oxidative stress capacity in alloxan induced diabetes rats. Dietary supplementation of Avicennia marina extract on immune protection and disease resistance in Amphiprion sebae against Vibrio alginolyticus. Ighodaro OM. Vireh (Avicenniaceae) is com- monly known as gray mangrove tree1. Collectively, these results suggest that the Avicennia marina leaf extract contains bioactive compounds with antimutagenic and antileukaemic effects. Evid Based Complement Alternat Med. Overall, exposure to high concentrations of glucose in cardiac muscle cells seems to increase the level of Bax protein (17). The results showed that the serum levels of IL-1β, IL-6, and TNF-α were significantly lower in diabetic groups receiving 100 and 200 mg/kg of A. marina than in the DM group, depending on the dose of injection (P < 0.05). , *, 1 2010;2(2):97-103. doi: 10.1111/j.1753-0407.2010.00068.x. Liver 16 , Issue. [PubMed: 22484242]. Open Nat Prod J. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties.The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats.In this laboratory research, a total of 40 male Wistar rats were … CC BY-NC 4.0. The liver tissue was then isolated and fixed in 10% formalin for histological evaluations. Another study demonstrated that lipid peroxidation increases in pancreatic cells of diabetic rats (26). Powered by Neoscriber ® 3.55. J Pharmacol Toxicol Methods. [PubMed: 23524027]. 2015. 2013;1831(10):1542-54. doi: 10.1016/j.bbalip.2013.03.001. Avicennia marina (Forssk.) Eur J Nutr. Avicennia marina (Avicenniaceae) is a species of mangrove tree used for treatment of small pox lesions in Persian folk medicine. [PubMed: 22800297]. Pages High glucose enhances IL-1β-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells. Researchers also showed that the levels of 8-hydroxydeoxyguanosine and 8-hydroxyguanine, as the markers of DNA oxidative damage, increased in the urine and liver tissue of all streptozotocin-induced diabetic rats (29). Increased inflammatory cytokines also have inhibitory effects on the glucose transporter type 4 (GLUT-4) gene, leading to increased insulin resistance (6). [PubMed: 22899998]. Conclusions: Avicennia marina (AM) was identified as a potential candi date for the treatment of AGA based on its Curr Pharm Des. Type 1 Diabetes Mellitus Results: Antioxidant, hypoglycemic, and neurobehavioral effects of a leaf extract of Avicennia marina on autoimmune diabetic mice. Innate inflammation in type 1 diabetes. Diabetes mellitus was induced by an intraperitoneal injection of 120 mg/kg of alloxan monohydrate. 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